Gastrointestinal disease test kit Anti-GPC

for anemia

• Use of porcine H+/K+ ATPase • Ready-to-use (exception: wash buffer) and barcoded reagents • Quality assured handling in routine laboratories • Short incubation times (60 min / 30 min / 15 min) at room temperature • Quantitative determination of IgG antibodies • Calibrated by use of an internal reference sample • Results expressed in U/mL • Excellent diagnostic sensitivity and specificity • High precision within the measurement range • CE marked • Automatable Intended Purpose The Anti-GPC is a quantitative immunoassay for the determination of IgG antibodies against gastric parietal cells of the gastric mucosa (GPC) in human serum. The Anti-GPC is intended as an aid in the diagnosis of pernicious anemia and type A gastritis in conjunction with other clinical and laboratory findings. The immunoassay is designed for manual professional in vitro diagnostic use. Diagnostic Relevance Pernicious anemia (Biermer‘s disease) is based on an undersupply of vitamin B12, which in turn can be due to a lack of intrinsic factor. Vitamin B12 and the Intrinsic Factor Vitamin B12 is essential for the formation of blood cells. It is formed by microorganisms, ingested with food, released in the stomach by proteolytic processes and bound to intrinsic factor (IF). The intrinsic factor is a glycoprotein produced in the parietal cells of the gastric mucosa. It protects the vitamin from decomposition and is used for its absorption in the small intestine. A lack of intrinsic factor can lead to an undersupply of vitamin B12 and thus to pernicious anemia.