Rapid inflammatory disease test FASTest® CRP

for dogsCRPserum

FASTest® CRP canine is a rapid immunochromatographic assay for the qualitative detection of C-reactive protein (CRP) in whole blood, plasma or serum of the dog. As response to tissue injury and inflammation, the body produces, among others, so-called acute-phase proteins (APP) in the liver. The C-reactive protein (CRP) is the most sensitive and fastest acute-phase protein of the dog, with low serum concentrations during normal homeostasis and a quick answer during and after beginning of inflammation. The function of CRP is, among others, stimulation of the unspecific immune defence by activation of scavenger cells and the complement cascade. The measurement of CRP in dogs is useful for the diagnostics and follow-up of inflammatory diseases. In healthy dogs, there is a low CRP level below 10 mg/l. A drastic increase in the CRP level occurs on inflammatory processes within few hours (Ø 24–28 h by a factor of 10 to 100) due to infections, immune disorders, neoplasia and traumata. As soon as the inflammation subsides through a successful therapy, the CRP level decreases rapidly within Ø24–28 h. Therefore CRP can be regarded as a real-time marker. Indicating inflammations, CRP is more sensitive than the determination of rectal temperature or leucocyte differential diagnostics. Another advantage of CRP determination is its independence to endogeneous or iatrogenic disturbing factors (e.g. glucocorticoids, stress). FASTest® CRP canine is a lateral flow immunoassay using highly specific monoclonal antibodies against dog CRP. It can be used with whole blood, plasma or serum of dogs for in-clinic and/or laboratory testing.