MileGREEN is a solvent, consisting of iso-paraffins and replaces xylene both at the clearing and mounting process. Moreover, it can be used for cleaning purposes for paraffin contaminated items, for example in HistosMATE module. When heated this solution becomes highly effective in the extraction lipids from biological tissue. MileGREEN is an almost odorless solvent and has the properties to solve fat and paraffin. Its formulation of low toxicity overcomes the drawbacks commonly associated with the xylene, a hazardous product for the human nervous system. MileGREEN also provides optimal structural preservation of fat cells structure, nuclear and cytoplasmic morphology.