Automated patch-clamp system Patchliner

whole-cellmedium throughputfor the pharmaceutical industry

The Patchliner is a fully automated planar patch clamp instrument recording from up to 8 cells simultaneously. With its vast experimental freedom and gigaseal data quality, the Patchliner is one of the most versatile patch clamp instruments on the market. The benefits the Patchliner offers include: Hardware: External & internal exchange Unlimited compound applications due to continuous waste removal Temperature control (see Applications) Cooled CellHotel Voltage & current clamp + dynamic clamp Available as Patchliner Quattro or Octo – 4 or 8 amplifier channels Single- & multihole chips, produced in-house Rseries compensation Applications: Voltage and ligand-gated ion channels Temperature-activated channels Recordings at physiological temperature Whole-cell & perforated patch clamp Cell lines, primary cells and stem cells Part of the CiPA validation study Minimized cell consumption Easy & customizable analysis tools The Patchliner is versatile yet robust, ideal for basic research of ion channel biophysics and mechanisms of action, and sophisticated assays including heat activation of TRP channels, activation of Ca2+-activated channels by internal exchange and fast external solution exchange with minimal exposure for ligand-gated ion channels such as nAChα7. The Patchliner is also an excellent tool for routine assays such as safety screening of hERG or other cardiac ion channels in line with the CiPA initiative.