Solution reagent kit NEXome XP Panel v1.0

for researchSNP

NEXome XP Panel v1.0 is an enhanced extended whole exome capture Panel. On the basis of NEXome Core Panel, it provides expanded coverage of clinically relevant variants in non-coding genomic regions, and includes the GENCODE annotation of protein-coding regions, and provides a comprehensive coverage of immunoglobulins (IG) and T cell receptors (TR) coding genes, and extends the target regions to SNP skeleton of whole genome，intronic regions related to common gene fusion in solid tumors and classical microsatellite loci, which spans a 45.9 Mb region of human genome. Product details Clinvar variants in non-coding region NEXome XP Panel v1.0 provides expanded coverage of clinically relevant variants in non-coding genomic regions. Expanded coding region coverage NEXome XP Panel v1.0 further includes the GENCODE annotation of protein-coding regions, and provides a comprehensive coverage of IG and TR coding genes. SNP skeleton of whole genome Based on the 1000 Genomes database, we mainly select >9,000 loci with high MAF values and high heterozygosity in the Chinese population, covering the entire human genome at approximately 300 Kb intervals. It provides richer and more evenly distributed information on the genomic composition based on the whole exome, and can be used for detection of CNVs and loss of heterozygosity. Common gene fusion in solid tumors Classical microsatellite loci The NEXome Core Panel itself covers a large number of microsatellite loci, and the addition of 15 optimally designed MSI classical loci facilitates the comparison between different