Automatic molecular screening system Dianthus

molecular interactionHTSfor drug discovery

It’s not surprising that the most important drug candidates and targets are super challenging when it comes to affinity screening. Immobilization-dependent SPR struggles with affinity screening campaigns for applications involving PROTAC binary and ternary complexes, fragment libraries, and intrinsically disordered proteins. These are precisely the applications where Dianthus excels. Now with Spectral Shift and TRIC, two methods for measuring molecular interactions, Dianthus delivers high-quality data, has the sensitivity to detect more true binders, and requires less assay development to give you results from real-life samples. Dianthus is a plate-based and microfluidics-free affinity screening platform. Measurements are in solution and mass-independent — ideal for succeeding at demanding screening campaigns. Finally find success with your challenging affinity screening campaigns Move your screening campaigns forward with results you can trust When faced with challenging screenings, most biophysical methods deliver poor-quality data at best, and some just don’t work. Dianthus delivers data with high signal-to-noise ratios that remove any uncertainty about your hits, especially when calculating affinity constants. So you trust your data and your decision-making. Get actionable results from real-life samples without spending too much time on assay development Some affinity screening methods only generate good data with pure samples, which delays projects and puts a lot of pressure on screening teams. With Dianthus you get high-quality data from real-life samples, so aggregates, impurities, or precipitates won’t hold you back.