Cardiovascular disease (CVD) is the number one cause of death wordwide1. The cause of CVD is atherosclerosis. Cardiovascular risk does not correlate with clinical symptoms until considerable atherosclerotic disease progression. Consequently, early accurate CVD risk assessment is part of an established clinical strategy of primary prevention. A number of guidelines have been established for the prevention, diagnosis, evaluation and management of CVD. The goal being the reduction of cardiac events such as acute heart attack (myocardial infarction, MI) and stroke. CVD risk assessment is therefore a key aspect of clinical care for all individuals between the age of 40-79.
Clinical CV risk factors include hypertension, diabetes mellitus, chronic kidney disease, obesity, cigarette smoking and family history. The most important biomarkers for CV risk determination are lipids including total cholesterol, triglycerides, LDL and HDL cholesterol. Early epidemiological studies associated both total cholesterol and LDL cholesterol to CV risk. Current studies have shown that there is discordance in quite a number of individuals based on the standard lipid profile. Thus, the determination of lipoprotein particle (LDL-P) numbers offers a more accurate risk assessment especially in those individuals with other comorbid conditions. A simple determination of total cholesterol with its subgroups HDL and LDL is thus no longer sufficient. As a consequence it is recommended to consult further parameters providing data beyond the conventional lipid panel.
numares offers an on-site technology for the assessment of cardiovascular risk, i.e. an in-depth lipoprotein analysis.