Prolactin, also known as lactotropin, is a protein best known for its role in enabling females to produce milk. While prolactin is secreted from the anterior pituitary gland in both men and women, women have slightly higher basal level of prolactin than men due to an estrogen-related rise at puberty and a corresponding decrease at menopause. During pregnancy, prolactin level increases progressively to 10 and 20 times of normal value, declining to non-pregnant levels by 3-4 weeks post-partum.
The determination of prolactin concentration is helpful in diagnosing hypothalamic-pituitary disorders. Microadenomas (small pituitary tumors) may cause hyperprolactinemia, which is sometimes associated with male impotence. High prolactin levels are commonly associated with galactorrhea and amenorrhea. Prolactin concentrations have been shown to be increased by estrogens, thyrotropin-releasing hormone (TRH), and several drugs affecting dopaminergic mechanism. Also, prolactin levels are elevated in renal disease and hypothyroidism, and in some situations of stress, exercise, and hypoglycemia.
Specification
Working range - 1.0-100.0 ng/mL
Reference range - * Female: <25 ng/mL
* Male: <20 ng/mL
Storage condition - Cartridge: 2-30 ℃
Detection buffer: 2-8 ℃
Shelf life - 24 months