Transplantation organ perfusion system metra®

liveron casters

How does the metra work? During normothermic machine perfusion with the OrganOx metra, the donor liver is continuously perfused with oxygenated blood, medications and nutrients at normal body temperature and near physiological pressures and flows. This means the liver is functional throughout preservation, enabling functional assessment and evidence-based decisions on whether to transplant a donor organ. Assessment of liver function prior to transplant with the metra may result in more donor livers being available for transplant.1 Conventional cold preservation involves storage of the liver at 4°C and aims to minimise liver degradation. The metra, however, recreates a near physiological environment by continuously perfusing the liver at near physiological pressures and flows with oxygen-carrying red blood cells at 37°C. The liver remains functional during preservation, producing bile, metabolising glucose and maintaining pH, allowing the objective assessment of organ performance prior to transplant. Via onboard blood gas analysis, the metra automatically measures and controls blood gases in the perfusate without user intervention. Design The metra has a rugged, robust design for ease of transport and safe storage when not in use. It has a battery for transportation when not on mains power and a self-regulating oxygen supply, removing the need to carry gas canisters.Automation The metra has a simple control panel with just three main buttons: start, stop and remove cartridge. The onboard automation allows automated control of flows, pressures, temperature and blood gases, providing the same perfusion conditions every time.