Cancer test kit PNAC-5101

tissuefor RT-PCR

IDH2 is frequently mutated in glioma, acute myeloid leukemia, and myelodysplastic syndromes. Mutations generally involve point mutations at the R140 and R172 residues of the protein. Mutations in IDH1 and IDH2 result in deleterious “gain of function”: instead of converting isocitrate to α-ketoglutarate, mutated IDH1 or IDH2 converts isocitrate to 2-hydroxyglutarate. 2-hydroxyglutarate inhibits other proteins involved in epigenetic regulation. FEATURES High sensitivity and specificity even with small amount of DNA (1% LOD with 10 ng wild/mutant type mixed DNA) Real-Time PCR based ready-to-use kit Short running time (within 3 hours)