Automatic media preparation system PT-DDS4

for dissolution testersheatingdegassing

The PT-DDS4 media preparation and degassing instrument is a vital part of a dissolution testing system. Deaerated media are critical to the reproducibility of dissolution results. The PT-DDS4 can prepare up to 25 litres of pre-heated media, which is degassed by a combination of heating, vacuum and circulation. The USP reference standard tablets, are used to perform a dissolution instrument suitability test after a successful physical parameter qualification (OQ). During this suitability test, the quality of degassing has a significant effect upon the test results obtained; as does vibration. Naturally, the mechanical “fitness” of the instrument has to be established and is usually achieved by performing the OQ prior to the USP suitability test. Low vibration levels, low wobble, correct tool centering and precise tool depth settings are just some of the factors which may affect a successful qualification – but media degassing is one of the most influential factors. The PT-DDS4 media preparation system has proven in many tests and in general operation, that its automated degassing and dosing procedure fulfills the requirements of both the FDA and USP and that the USP Prednisone qualification test (PVT) will successfully be achieved. The prepared media (water or buffer) can either be filled directly into the media tank or it can be automatically primed using the on-board vacuum pump and the internal liquid level sensor which controls the pre-filling volume. Select your method of choice and enter the maximum volume. It is also possible to mix a buffer using de-mineralised water and a buffer concentrate, if the on-line buffer mix option is installed.