Protein molecular imaging system FRAP®

automatedfor molecular biologyfluorescence recovery after photobleaching

Prescreen for LCP Crystal Growth Determine Protein Mobility High protein mobility and fast diffusion rates correlate well with crystallization conditions. Save Time + Money Rule Out Sub-Optimal Conditions Focus your research on those conditions conducive to LCP crystal growth. Convenient + Easy-to-Use Fully Automated Analysis Initiate a complete analysis of your plate with a few clicks and store all your data in one spot. Find the optimal conditions for LCP crystal growth, without waiting on your crystals. Prior to setting up crystallization experiments, you can quickly screen Lipidic Cubic Phase (LCP) conditions using Fluorescence Recovery After Photobleaching (FRAP). FRAP is an optical technique that assesses how easily protein is moving about in an LCP drop. If protein is aggregated, or the LCP structure is collapsed, the protein will not diffuse and therefore never crystallize. FRAP is a great tool to accelerate crystallization methods and rule out suboptimal conditions without having to wait on the crystals actually growing. The automated FRAP imaging system was designed specifically for performing the FRAP assay on 96-well LCP crystallization setups. The entire system is automated and user-friendly requiring a few clicks of a button to initiate a complete analysis of your plate. All of the results and analyses are integrated into FORMULATRIX' protein crystallography specific software lab management software (ROCK MAKER and ROCK IMAGER).