Pneumonia assay kit Q-Plex™

IgGStreptococcus pneumoniaeserum

The Q-Plex™ Human Pneumococcal IgG (14-Plex) plate detects antibodies recognizing 14 common serotypes individuals are vaccinated against while the second kit, the Q-Plex™ Human Pneumococcal IgG (9-Plex), detects antibodies recognizing 9 additional serotypes commonly used as vaccination targets. Limits for these assays were set using the 007sp Human Anti-Pneumococcal capsule Reference Serum. Principle of the Assay The Q-Plex™ Human Pneumococcal IgG (9-Plex) is a chemiluminescent multiplex ELISA run on a 96-well plate. This pneumococcal serotype test quantitatively measures antibody levels corresponding to the serotypes found in pure polysaccharide vaccines such as the Pneumovax®23 vaccine as well as protein conjugated vaccines such as Prevnar 7, Prevnar 13, Prevnar 20, and Vaxneuvance. Antibodies play an essential role in the protection against pneumococcal disease. In humans, serum antibodies typically act against the polysaccharide capsule in a serotype specific manner. There are multiple vaccination options for protection against S. pneumoniae, with the major difference being the number and composition of specific serotypes present in the vaccine. Background The bacterium Streptococcus pneumoniae can cause potentially deadly infections in children and the elderly, including pneumonia and meningitis. Risk of infection and disease severity varies with age of the patient and a host of other factors including geographical location, ethnic background, and time of year. More than 90 serotypes are known, though less than 25 are responsible for most cases, with virulence often differing between serotypes.