Gastrointestinal infection test kit RIDA®GENE

adenovirusrotavirusnorovirus

For in vitro diagnostic use. RIDA®GENE Viral Stool Panel I is a multiplex real-time RT-PCR for the direct, qualitative detection and differentiation of norovirus, rotavirus, adenovirus 40/41 and astrovirus in human stool samples. The RIDA®GENE Viral Stool Panel I multiplex real-time RT-PCR is intended for use as an aid in diagnosis of gastroenteritis caused by norovirus, rotavirus, adenovirus 40/41 and astrovirus, respectively. General information: Acute Gastroenteritis is one of the main causes of morbidity and mortality worldwide. Especially in children, enteral viruses are the primary cause of gastroenteritis. In the US, viral infections cause approximately 30.8 million cases of gastroenteritis, yearly. The most important pathogens causing diarrhea are norovirus, rotavirus, adenovirus and astrovirus. Noroviruses belong to the family of Caliciviridae and are single-stranded RNA (ssRNA) viruses. Gastroenteritis caused by norovirus is manifested by severe nausea, vomiting and diarrhoea. Noroviruses are egested by stool and with the vomit. They can be grouped in 7 genogroups with currently over 30 genotypes and a multiplicity of clades. So far, human pathogens have only been described from genogroup I (GI) with 9 genotypes, from genogroup II (GII) with 22 genotypes and from genogroup IV (GIV) with two genotypes. In the US, it is estimated, that more than 21 million cases of acute gastroenteritis, 70,000 hospitalisations and 800 deaths are caused by norovirus infections each year. Rotaviruses belong to the Reoviridae familiy of non-enveloped icosahedral double-stranded RNA (dsRNA) viruses.