Gastrointestinal infection test kit PG2225

bacteriaEscherichia colienterobacteriaceae

For in vitro diagnostic use. RIDA®GENE ETEC/EIEC is a multiplex real-time PCR for the direct, qualitative detection and differentiation of the virulence-factor genes of ETEC and EIEC/Shigella spp. in human stool samples and cultures. RIDA®GENE ETEC/EIEC multiplex real-time PCR is intended for use as an aid in diagnosis of gastroenteritis caused by pathogenic Escherichia coli and Shigella spp., respectively. General information: Escherichia coli (E. coli) are gram negative, facultatively anaerobic rod bacteria, which move by peritrichal flagellation and belong to the Enterobacteriaceae family. E. coli are part of the normal intestinal flora of humans and many farm animals and are generally nonpathogenic. Some E. coli strains are pathogenic to humans through the acquisition of certain virulence factors (e.g. genes for toxins). The six known intestinal pathogenic E. coli: enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), enterotoxic E. coli (ETEC), enteroinvasive E. coli (EIEC), EAEC enteroaggregative E. coli und diffusely adherent E. coli (DAEC) can be differentiated by the virulence factors. Enterotoxigenic E. coli (ETEC) are important intestinal pathogenic E. coli. ETEC is the most common cause of traveller’s diarrhea that affects persons travelling to developing countries. 30 – 60 % of all traveller’s diarrhea cases are caused by ETEC. 11 – 16 % of returning travellers from developing countries are infected by ETEC. Among children below 5 years of age in developing countries, ETEC accounts for about 210 million cases of diarrhea and about 380,000 deaths annually.