The isolated perfused liver and isolated perfused kidney models are reliable standards for studies in pharmacology. The donor animal in most of these studies has been the rat but recent interest has centered around the use of the mouse model. The Radnoti Liver/Kidney system can be used in constant pressure or constant flow, re-circulating or non-re-circulating experimental protocols.
Radnoti in-vitro liver/kidney chamber:
liver is removed from the donor.
suitable for both mouse and rat
water-jacketed and circular with a glass lid assembly.
flat bottomed with a side mounted drain.
Three ports permit the introduction of two cannula for organ perfusion and one for the removal of bile samples.
Flexible inlet and outlet lines are attached to luer hubbed, paired stainless steel cannula that are provided for mounting the liver or kidney.
The lid of the chamber has a central threaded mount for the attachment of a fiber optic cable, used for optical measurements of endogenous nucleotides or various fluorescent indicators.