The Randox bilirubin assay has a correlation coefficient > 0.99% CV when compared to commercially available methods.
Direct-Total
Direct & Total assays available
Randox offer both direct & total bilirubin assays offering choice and flexibility.
Liquid ready-to-use
The Randox bilirubin assay is available in a liquid ready-to-use format for convenience and ease-of-use.
Calibrator & Controls
Calibrator and dedicated control available
Calibrator and dedicated control available offering a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox bilirubin assay on a variety of clinical chemistry analysers.
PHYSIOLOGICAL SIGNIFICANCE
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Bilirubin is a metabolite of haem, derived from haem-containing proteins, including myoglobin, haemoglobin and various P450 enzymes, that serves to coordinate iron in various proteins. Half of it is excreted into bile and the rest contributes to blood bilirubin turnover 1. It is mainly produced in the spleen and liver but can also occur elsewhere in the body by macrophages and renal tubular cells 2. The internal hydrogen bonding causes it to be water-insoluble and so required enzyme-mediated glucuronidation in the liver for biliary excretion. Under normal conditions, it is mostly unconjugated and bound tightly to albumin
CLINICAL SIGNIFICANCE
Bilirubin is a metabolite of haem, derived from haem-containing proteins, including myoglobin, haemoglobin and various P450 enzymes, that serves to coordinate iron in various proteins. Half of it is excreted into bile and the rest contributes to blood bilirubin turnover 1.