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Enzyme reagent BR2361
diagnosticfor clinical chemistryliquid

Enzyme reagent - BR2361 - Randox Laboratories - diagnostic / for clinical chemistry / liquid

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Characteristics

Type: enzyme
Applications: diagnostic, for clinical chemistry
Format: liquid
Tested parameter: myoglobin, iron, total bilirubin

Description

The Randox bilirubin assay has a correlation coefficient > 0.99% CV when compared to commercially available methods. Direct-Total Direct & Total assays available Randox offer both direct & total bilirubin assays offering choice and flexibility. Liquid ready-to-use The Randox bilirubin assay is available in a liquid ready-to-use format for convenience and ease-of-use. Calibrator & Controls Calibrator and dedicated control available Calibrator and dedicated control available offering a complete testing package. Applications available Applications available detailing instrument-specific settings for the convenient use of the Randox bilirubin assay on a variety of clinical chemistry analysers. PHYSIOLOGICAL SIGNIFICANCE Bilirubin is a metabolite of haem, derived from haem-containing proteins, including myoglobin, haemoglobin and various P450 enzymes, that serves to coordinate iron in various proteins. Half of it is excreted into bile and the rest contributes to blood bilirubin turnover 1. It is mainly produced in the spleen and liver but can also occur elsewhere in the body by macrophages and renal tubular cells 2. The internal hydrogen bonding causes it to be water-insoluble and so required enzyme-mediated glucuronidation in the liver for biliary excretion. Under normal conditions, it is mostly unconjugated and bound tightly to albumin CLINICAL SIGNIFICANCE Bilirubin is one of the most common diagnostic tests utilised in the diagnosis and monitoring of hepatic dysfunction. It is impaired in cholestatic and parenchymal liver diseases. The most common condition associated with elevated levels is jaundice (a clinical sign of hyperbilirubinaemia),

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Enzyme reagent BR2361diagnosticfor clinical chemistryliquid

Characteristics

Description

Catalogs

Other Randox Laboratories products

Diagnostic Reagents

Enzyme reagent BR2361
diagnosticfor clinical chemistryliquid