Solution reagent CE190
for clinical chemistryproteincolorimetric

solution reagent
solution reagent
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Characteristics

Type
solution
Applications
for clinical chemistry
Tested parameter
protein
Method
colorimetric
Storage temperature

Max.: 8 °C
(46 °F)

Min.: 2 °C
(36 °F)

Description

The Randox methodology was compared against other commercially available methods and the Randox cholinesterase (butyryl) reagent showed a correlation coefficient of r=0.9959 Other features of the Cholinesterase (Butyryl) (BCHE / BuCHE) reagent Colorimetric method Lyophilised reagents Correlation coefficient of r=0.99 when compared with another commercially available method Measuring range 455-28722U/l What is the Cholinesterase (Butyryl) (BCHE / BuCHE) assay used for? What is cholinesterase (butyryl)? Cholinesterase (butyryl) (BCHE / BuCHE), also known as pseudocholinesterase, is a protein coding gene and is a serine hydrolase synthesised in the liver and is responsible for catalysing the hydrolysis of numerous choline esters. It can be found in the liver, intestinal mucosa, plasma, pancreas and the white matter of the central nervous system of mammals. The Randox Cholinesterase (butyryl) reagent is used for the quantitative in vitro determination of BCHE in serum and plasma. BCHE can be used to diagnose cholinesterase (butyryl) deficiency and curariform drugs toxicity. The Randox Cholinesterase (butyryl) reagent can also be used as a diagnostic and therapeutic marker for Alzheimer’s disease as BCHE activity progressively increases in patients with Alzheimer’s disease whereas acetylcholinesterase activity remains the same or declines. In Alzheimer’s disease, BCHE is found in association with beta-amyloid plaques and the cerebral cortex, whereas it is not commonly found in any other case. A study carried out by NCBI found that when the BCHE gene is not found in the brain, there are up to 70% less beta-amyloid plaques.

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MEDICA 2024
MEDICA 2024

11-14 Nov 2024 Düsseldorf (Germany) Hall 3 - Stand A08

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