Solution reagent FN series

for clinical chemistryproteinferritin

A correlation coefficient of r=0.99 was displayed when the Randox ferritin assay was compared to commercially available methods. Limited interference The Randox ferritin assay has shown to have limited interference from bilirubin, haemoglobin and triglycerides. Applications available Applications available detailing instrument-specific settings for the convenient use of the Randox ferritin assay on a variety of clinical chemistry analysers. Calibrator and controls available Calibrator and controls available offering a complete testing package. Ferritin is an iron storage protein. It is the primary iron storage mechanism and is critical to iron homeostasis. As an iron store, ferritin has two roles 1. Provides a reserve of iron, which can be transported for the synthesis of molecules such as cytochromes, haemoglobin and iron-sulphur compounds. Safe-guards cells, DNA, lipids and proteins from the potential toxic effects of iron. Ferritin is a vital component of iron homeostasis. It acts as as a ferroxidase, converting Fe(II) to Fe(III) as iron is internalised and sequestered in the ferritin mineral core. Iron is toxic in cellular systems due to its capacity to generate reactive oxygen species (ROS) which directly damages cells, DNA, lipids and proteins Iron deficiency without anaemia is a diagnostic challenge, as it commonly goes unrecognised for a long period of time as the patient is asymptomatic. Ferritin is the most sensitive and specific test used in the diagnosis of iron deficiency, especially when a patient presents with symptoms of iron deficiency anaemia, but their full blood count is normal