Enzyme reagent PD410

for clinical chemistryG6PDfor DNA

A correlation coefficient of r=0.9903 was displayed when the Randox G6PDH assay was compared to commercially available methods. Precision Excellent precision The Randox G6PDH assay displayed a precision of <4.65% CV. Calibrator & Controls Dedicated G6PDH controls available Dedicated G6PDH controls available offering a complete testing package. Applications available Applications available detailing instrument-specific settings for the convenient use of the Randox G6PDH assay on a variety of clinical chemistry analysers. PHYSIOLOGICAL SIGNIFICANCE The G6PD gene provides the instructions for marking the glucose-6-phosphate dehydrogenase (G6PDH) enzyme 1. G6PDH is a cytosolic enzyme located on the long arm of the X-chromosome of bodily cells and so is an inherited x-linked disorder. G6PDH is involved in the normal processing of carbohydrate and the prevention of cellular damage from reactive oxygen species (ROS). In doing so, G6PDH provides substrates to prevent oxidative damage. G6PDH plays a critical role in red blood cells, protecting them from damage and premature destruction. The two main products of G6PDH are: ribose-5-phosphatase which is important for DNA, the chemical cousin of RNA; and NADPH which protects the body from ROS G6PDH DEFICIENCY Glucose-6-phosphate dehydrogenase (G6PDH/G6PD) deficiency is the most common enzyme deficiency in the pentose phosphate pathway, affecting more than 400 million people globally. G6PDH deficiency is an X-linked recessive disorder mainly affecting RBC’s 2. A defect in the G6PDH enzyme results in premature haemolysis (break down of RBC’s).