Enzyme reagent RS504
glutathione peroxidasefor clinical chemistryprotein

enzyme reagent
enzyme reagent
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Characteristics

Type
enzyme, glutathione peroxidase
Applications
for clinical chemistry
Tested parameter
protein, hydrogen peroxide
Method
enzymatic

Description

The Randox Ransel assay utilises the enzymatic method enabling the sensitive and accurate detection of glutathione peroxidase. Precision Excellent precision The Randox Ransel assay displayed a within run precision of <4.86% CV. Correlation Excellent correlation A correlation coefficient of r=0.9829 was displayed when the Randox Ransel assay was compared to commercially available methods. Calibrator & Controls Dedicated calibrator and control available Dedicated Ransel calibrator and control available offering a complete testing package. Applications available Applications available detailing instrument-specific settings for the convenient use of the Randox Ransel assay on a variety of clinical chemistry analysers. Glutathione peroxidase (GPx) is a reactive oxygen species (ROS), generated by bodily cells via mitochondrial and enzymatic sources. It is vital that GPx levels are reviewed as it can cause oxidative damage to membrane lipids, proteins and DNA. GPx is an intracellular antioxidant enzyme that enzymatically converts hydrogen peroxide to water (detoxification). Hydrogen peroxidase is vital for the maintenance of normal thiol redox-balance, mitochondrial function, and growth factor-mediated signal transduction. By converting hydrogen peroxidase to water, GPx aids in modulating these processes 1. GPx also contributes to cell signalling and oxidative protein folding 2.

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