Solution reagent kit KAPA HyperExome

DNA polymeraseNGSSNP

The KAPA HyperExome Probes are Roche’s brand new Whole Exome Sequencing solution, based on the next generation KAPA Target Enrichment Probe’s technology. Their design and technology provide broad, relevant database coverage and high sequencing efficiency. The product has been extensively optimized through design and manufacturing processes to increase coverage in hard-to-sequence regions for a more uniform and complete exome. Based on customer feedback, Roche Sequencing scientists created the KAPA HyperExome Probes, a sequencing efficient design with actionable and well-annotated content. KAPA HyperExome Probes are targeting the GRCh38/hg38 genome assembly (coordinates for hg19 annotation are also provided) by covering the CCDS, RefSeq, Ensembl, GENCODE and ClinVar genomic databases in an efficient ~43 Mb capture target size, including 387 sample tracking SNPs to streamline sample identity tracking throughout the WES workflow. Features and benefits of KAPA HyperExome Probes Better by design - Uncover difficult regions and access more content from important genomic databases Validated with the KAPA HyperCap Workflow v3.0 for high sequencing efficiency by superior uniformity and low duplication rates Higher result confidence with >98.7% sensitivity and >99.7% specificity of SNP detection Stronger enrichment by high fidelity probes that are manufactured with KAPA HiFi DNA Polymerase and target both DNA strands Streamline your sample identity tracking to new levels of result confidence by intrinsically targeting 387 sample tracking SNPs Experience consistent quality and efficiency with NGS probe pool QC and larger reaction pack sizes