Allograft bone substitute nanOss® Advanced

for orthopedic surgerygranules

roducts & Implants nanOss® Advanced Bone Graft Substitute nanOss® Advanced Bone Graft Substitute is composed of nano-structured hydroxyapatite granules and an open structured engineered collagen carrier. Features & Benefits Nano-structured hydroxyapatite (HA) provides more surface area which allows increased potential for cell attachment. Nano-structured HA is similar to bone, which increases its potential to remodel into new bone. A 12-month peer-reviewed multi-center study of 46 patients showed 93 percent of the total individual sites treated exhibited posterolateral bridging bone.* *C. Lauryssen MD*, S. Robbins MD* & M. Songer MD*. Lumbar Spinal Fusion Results Using nanOss: One Year Follow-Up. 2012 *Served as clinical evaluator/consultant of nanOss in posterolateral spine fusion and compensated for time summarizing patient oucomes, also were shareholders or option holders of Pioneer Surgical stock at the time they authored the study. Sterilization nanOss is provided sterile by prior exposure to gamma irradiation. nanOss cannot be resterilized by any method. Indications nanOss is intended for bony voids or gaps that are not intrinsic to the stability of bony structure. The product is indicated to be gently packed into bony voids or gaps in the skeletal system (i.e., extremities, posterolateral spine, and pelvis). nanOss must be mixed with autogenous blood or sterile saline for use in the extremities or pelvis. nanOss must be mixed with bone marrow aspirate and autograft bone as a bone graft extender in the posterolateral spine.