Tissue organ bath emkaBATH

benchtopisolated

emkaBATH is a type of tissue bath setup, designed for contractile measures in tissues such as aortic, tracheal, iliac, and papillary muscles, and/or microvessels such as veins, small arteries, and lymph vessels. The system provides heated, oxygenated, and nutrient-rich perfusate to the tissue with or without drug administration and electrical stimulation. Tissue baths are widely used to study the effects of agonists and antagonists on tissue contractility. Dose-response curves allow for characterization of a drug’s pharmacological profile and the calculation of EC50 or Emax. Vascular reactivity study using tissue bath systems The impact of different drugs on relaxation or contraction of the endothelium or vascular smooth muscles can be investigated using isolated tissue bath protocols. This application note includes: - An introduction about the crucial role of the endothelium - A focus on recent studies where tissue baths were used to investigate cardiovascular diseases: Atherosclerosis, hypertension, heart failure, diabetes and metabolic syndrome - A protocol explaining how to set an experiment to study rodents aorta rings on tissue bath Applications RESPIRATORY APPLICATIONS CARDIOTOXICITY VASCULAR BIOLOGY HEART FAILURE & CARDIAC MODEL DEVELOPMENT ARRHYTHMIA BEHAVIORAL STUDIES INFECTIOUS DISEASE & MEDICAL COUNTERMEASURES TOXICOLOGY SAFETY PHARMACOLOGY TRAUMATIC BRAIN INJURY SLEEP DISORDERS SEIZURE & EPILEPSY