Antibody 162041

immunoturbidimetricfor turbidimetryliquid

Cystatin C is a non-glycosylated basic protein produced at a constant rate in nearly every nucleated cell of the human body. The cystatin C concentration has been shown to be independent of muscular mass, inflammatory diseases, sex, age or diet. It is freely filtered through the normal glomerular membrane and almost completely reabsorbed and catabolized by the proximal tubules.2,3 In studies cystatin C has been shown to be a sensitive early indicator of decreased renal function. These properties make it a superior marker of Glomerular Filtration Rate (GFR) compared to the traditional measurement of creatinine. The Clinisciences’ Cystatin C assay is a convenient cost effective dual liquid stable latex enhanced immunoturbidimetric method for this critically important emerging marker in the early detection and diagnosis of renal disease. Cystatin C in the sample binds to the specific anti-Cystatin C antibody, which is coated on latex particles, and causes agglutination. The degree of the turbidity caused by agglutination can be measured optically and is proportional to the amount of Cystatin C in the sample. The assay is highly sensitive with a sensitivity of 0.1 mg/dL, and an extended linear range up to 8.0 mg/dL. Reagents are stable for 24 months from date of manufacture when stored at 2°-8°C.