Body plethysmograph HOP-2M

for animals

The head-out plethysmography system adopts a special design to isolate the neck of the small animal from the body, expose the mouth and nose to the outside, and measure the gas volume and pressure changes in the chamber containing the thorax in real time. Product Description (Head-Out) The head-out plethysmography system adopts a special design to isolate the neck of the small animal from the body, expose the mouth and nose to the outside, and measure the gas volume and pressure changes in the chamber containing the thorax in real time. Glaab et al. used mACh stimulation on asthmatic mice and took the mAh amount (EF50) when the mid-expiratory flow (EF50) dropped by 55% as an index to indicate the sensitivity of the bronchial response. The study proved that EF50 has a better correlation with RL and CL The correlation can better reflect the mechanical dynamics changes of the respiratory system. Features During the measurement process of the head-out plethysmography system, the animal remains conscious and does not require anesthesia. This avoids the impact of traumatic tracheotomy and anesthesia, allowing a simple and fast experimental process, and is suitable for long-term follow-up research. In addition, the system can be expanded and connected to a nebulized drug delivery device to administer nebulized drugs to animals to establish models of respiratory diseases such as cough and asthma. The system can detect and record changes in vital respiratory parameters and airway hyper-responses during stimulation to evaluate bronchoconstriction. No surgery is required, and the operation is simple.