Body plethysmograph

for animals

Product Description The head-out plethysmography system (Head-Out Plethysmography) adopts a special design to separate the neck of the small animal from the body, and expose the mouth and nose to the outside, and measure the gas volume and pressure changes in the chamber containing the thorax in real time. Glaab et al. used mACh stimulation on asthmatic mice, and took the mAh amount (EF50) when the mid-expiratory flow (EF50) dropped by 55% as an index to indicate the sensitivity of the bronchial response. The study proved that EF50 has a better correlation with RL and CL The correlation can better reflect the mechanical dynamics changes of the respiratory system. Applicable Fields l Asthma l Lung Fibrosis l COPD l Acute Respiratory Disorders l Model Development l Safety Assessment l Toxicology During the measurement process using the Head-out Plethysmography System, the animal remains conscious and does not require anesthesia, which avoids the impact of traumatic tracheotomy and anesthesia, allowing a simple and fast experimental process, and is suitable for long-term follow-up research. l In addition, the system can be expanded and connected to an nebulized drug delivery device to administer nebulized drugs to animals to establish models of respiratory diseases such as cough and asthma models. The system can detect and record changes in vital respiratory parameters and airway hyper-responses during the excitation process to evaluate bronchoconstriction. l No surgery is required and the operation is simple. l Animals are conscious and results are not affected by anesthesia and surgery.