Kidney disease assay kit N Latex

cystatin Ccreatinineserum

Renal disease often progresses undetected, because kidney impairment does not cause pain. This is why chronic kidney disease is not diagnosed until patients show symptoms of an advanced stage of the disease. In the early stages of disease, laboratory testing is the most efficient and sensitive way to detect reduction in renal function.1 Cystatin C shows increased sensitivity to renal dysfunction compared to serum creatinine, especially in the early stage of kidney disease characterized by a mild reduction in glomerular filtration rate. The N Latex Cystatin C Assay: Is suitable for both serum and plasma specimens Has low imprecision (total CV <5%) Runs on the Atellica® NEPH 630 System2, BN™ II System, and BN ProSpec® System Features & Benefits Cystatin C is a nonglycated, low-molecular-weight (13 kDa) protein that is synthesized by all nucleated cells. It is produced at a constant rate regulated by a housekeeping gene.3 Cystatin C is freely filtered by the glomerulus, and there is no tubular secretion or any extrarenal elimination. In addition, cystatin C is not affected by muscle mass, diet, gender, or inflammation. The relevance of determining cystatin C for diagnosis in CKD is included in the international KDIGO (Kidney Disease Improving Global Outcomes) guidelines. No tubular secretion; sensitive in the creatinine-blind range3 Higher sensitivity in early disease Independent of age, sex, and muscle mass3 Constant relationship between cystatin C and glomerular filtration rate (GFR) at 1 year of age and older Single reference range: 0.62–1.11 mg/L in children and adults ranging in age from 1 to 78 years Sensitive detection of declining GFR with aging