Toxicology assay kit N Latex CDT

alcoholserumimmunoassay

The N Latex CDT assay for use on Atellica® NEPH 630, BN™ II and BN ProSpec® Systems provides a highly specific screening method for the detection of alcohol abuse. The CDT level increases and decreases with the amount of alcohol consumed; therefore, many different applications are possible, such as differential diagnosis of alcohol-induced versus nonalcohol-induced diseases, legal applications (e.g., for regranting of driver’s license), workplace testing, or forensic toxicology. Fully automated immunoassay with no sample pretreatment required Highly specific monoclonal antibody that directly detects CDT Automatic calculation of %CDT by running CDT and transferrin assays simultaneously Fast availability of results—within 20 minutes (total assay time) Random-access capability Reliable results—excellent recovery between labs, systems, and lots Features & Benefits Carbohydrate-deficient transferrin (CDT) is regarded as a very specific marker for identifying excessive alcohol consumption and monitoring abstinence during outpatient treatment. Regular alcohol consumption of more than 50–80 g of ethanol per day for at least 2 weeks can result in a changed glycosylation pattern of transferrin, leading to a higher rate of isoforms lacking one or both entire carbohydrate chains. These isoforms (disialo- and asialotransferrin) are collectively named carbohydrate-deficient transferrin (Figure 1). After approximately 2–4 weeks of abstinence, CDT concentrations usually return to normal levels.