Aerosol generator PreciseInhale®

<100 mg of substance for a complete PK-study Precision dosing, <10% SD Flexible aerosol sources: Dry Powder (API) Nebulized solution Inhalers (DPI/ pMDI) IVIVC – minimized translational errors 3R –reduce, refine and replace animal tests Because the aerosol produced by PreciseInhale® is controlled, it is easily exposed in a range of exposure modules. The aerosol can be sourced from dry powders, inhalers or nebulized solutions, optimizing conditions for a wide range of substrates. PreciseInhale® works as an exposure platform for small-scale inhalation experiments by precisely dosing animals in vivo, lungs ex vivo, and depositing material for in vitro exposure and dissolution testing. Separating aerosol generation and dispensing Aerosols are generated with a high-power air jet of 10-160 bar pressure. The energy is then siphoned off, leaving a plume of aerosol that is ‘pulled’ into a fine stream by a vacuum pump, enabling it to be dispensed separately across a range of exposure modules. PreciseInhale®’s software monitors and measures aerosol in real time. Automated software and a light-scattering device maps and measures the aerosol concentration and breathing pattern in real time. This enables researchers to customize their aerosol to their exact needs, and generates detailed voluminous PK data, including particle size distribution data and Tmax and Cmax curves