Thermal gradient analgesimeter 35300

for animal researchfor micefor rats

The hot cold plate test has been the gold standard test for thermal pain tests in rodents for decades. Through the years the devices have been improving and the techniques have become more sophisticated, adding to constant temperature methods also other ones. The Ugo Basile Hot/Cold plate test includes all the latest technologies necessary to run constant temperature, linear ramping temperature (toward hot or toward cold) and complex temperature ramps thanks to the included X-Pad software. Moreover, the new model includes a keypad (cabled or optional Bluetooth) to score pain endpoints or stereotyped behaviors. Temperature range goes from -5° to 65°C and animal holders of different heights are available. Background Motor (or vocal) responses are normally the endpoints for thermal sensitivity tests and this has been true for hot temperatures and cold temperatures to study hyperalgesia and allodynia. More recently, the introduction of tamping devices, capable to increase the temperature from a starting point to an end point at given time rate, have largely improved the ability to differentiate between hyperalgesic and allodynic responses. The hot/cold plate method is a very traditional one and had the advantage of having unrestrained animals, however, a large variety in scoring methods can be found in the literature, and it depends on the visual scoring of the experimenter herself. Some labs use the first hind paw lick as test endpoints; others use the frequency of licks over a certain time window, other use jumping or vocalizations.