Thermal gradient analgesiometer 35550

for animal researchfor mice

The TGR can clearly discriminates temperature-dependent phenotypes or temperature dependent drug effects. It records and analyses thermal preference phenotyping in mice. For neuropathic pain studies, peripheral neuropathy, temperature sensitivity and insensitivity assessment in basic research, phenotyping and drug screening. The animal is freely moving, its position is tracked by a camera, and no user intervention is required to gather time spent in each temperature zone (12 zones in duplicate) and many other parameters. In the TGR mice can freely move around the ring floor, thereby avoiding the stereotypical habit that mice have of staying in a corner, as occurs in rectangular systems. It is a cost effective and bias-free tool to obtain reproducible data in a very broad range of thermal stimulation experiments. Background The cellular and molecular mechanisms of temperature sensing receptors (e.g. transient receptor, TRP, channels) and thermoregulation are the subject of intensive studies in neuropathic pain, peripheral neuropathy and temperature preference in general. The novel circular thermal gradient assay opens new opportunities for thermal preference and avoidance and addresses limitations imposed by classic linear equipment (lack of animal freedom, limited thermal choice, inability to make discerning exploratory behaviour, experimental biases). The TGR is based on the paper "Comprehensive thermal Preference Phenotyping in Mice using a Novel Automated Circular Gradient Assay” The TGR can clearly discriminate temperature-dependent phenotypes or drug effects