Von Frey analgesiometer 38450

for animal researchfor micefor rats

Touch sensitivity in unrestrained animals is traditionally tested with Von Frey filaments, which is a tedious and experimenter-dependent assay. The Electronic Von Frey system solves the multiple measurement (i.e. multiple filaments) issue and the experimenter bias by using a hand-held force sensor with a rigid metal. The scientist gradually increases the force applied to the animal paw, until the peak detector scores the animal paw withdrawal (or the user scores it manually with the included pedal). Force ranges are selectable in the 0-50, 0-200 and 0-1500 grams with a 0.1 grams sensitivity and software tools are included to aid a linear application of the force (rate-meter and slope). The system is battery or mains powered and comes with software included and data export in CSV. One model for Mice or Rats in modular enclosures (up to 6 rats or 12 mice; optional with Modular Animal Enclosures and Grid Platform, available in 2 heights, 40 or 80 cm). Background Von Frey filaments are still a productive way to evaluate behavioral responses of neuropathic pain in preclinical and clinical research, but they are time consuming and subject to experimenter bias; for this reason Ugo Basile developed a hand held Electronic Von Frey test with automated paw withdrawal detector. It is important that the application of the force is always perpendicular, with a preset amount of grams and at a predefined rate, which can be controlled with the provided tools (rate-meter on the control unit and slope on the software).