Reagent exchange unit Big Tuna

Cut loose from manual buffer exchange Buffer exchange and sample concentration are the time consuming, hands-on chores you have to deal with before all the things you really want to do. Big Tuna automates exchange to formulate, concentrate and clean up proteins or gene therapy vectors like AAVs, LNPs, and VLPs — with just 30 mins of setup time. Skip the slow and manual ways of prepping samples to free yourself up for other critical work. AAV LNP VLP mRNA & DNA Protein Go big or keep it small Big Tuna serves up two different plate-based formats that let you exchange and concentrate 24 or 96 samples in parallel. Use Unfilter 96 to exchange as little as 100 μL for up to 96 different samples in a run. Unfilter 24 lets you go big and exchange as much as 8 mL on up to 24 samples. With different molecular weight cutoff options, you always have the right Unfilter for the job. Hand it off Big Tuna keeps buffer exchange even across the plate with its unique pressure-based UF/DF process and gentle mixing. Its acoustic sensor measures the volume in every well before and after each cycle to track every sample’s exchange rate. Then Big Tuna figures out on the fly how much buffer to add to even things out. Get concentrated Dilute samples are a giant pain and hard to handle. Big Tuna can concentrate 48 mL down to 8 mL — freeing you from all the fuss. Follow up with buffer exchange to easily get your AAVs and other low-concentration, high-volume samples right where you need them to be. Be a control freak Buffer exchange doesn’t have to be a shot in the dark or keep you anchored to the bench. Use the software wizard to drag and drop your samples and buffers into place,