Infectious disease test kit ODZ-405

for serologyIgGfor BK virus

ELISA-VIDITEST anti-BKV IgG kit is intended for the detection of specific IgG antibodies to polyomavirus BK (BKV) in human serum and plasma. Recombinant antigens used in the kit do not cross-react with other polyomaviruses (polyomavirus JC, Merkel cell polyomavirus). The kit is used for the serological diagnostics of diseases caused or associated with BKV (e.g. BK-viral nephropathy, haemorrhagic cystitis, urethral stenosis, infections of upper and lower respiratory tract mainly in immunodeficient patients) and for the risk assessment of infection transmission and subsequent complications in graft acceptors. Anti-BKV antibodies are present in 50% to 80% of adult population. Primoinfection occurs mostly during childhood and in most of the cases it is asymptomatic or brings on an acute respiratory disease and then continues to the latent phase, which is characterised by long-term presence of anamnestic IgG antibodies in serum. In latently infected persons the virus can repeatedly reactivate or they can be re-infected by other BKV serotype. Reactivation/reinfection can be accompanied by temporary viremia or viruria; and in immunodeficient persons it can cause various diseases of urinary tract (haemorrhagic cystitis, urethral stenosis), kidneys (BK-viral nephropathy), central nervous system (encephalitis, polyradiculoneuritis), lungs (intersticial pneumonitis) or vasculitis. Absence of anti-BKV antibodies may indicate patient’s susceptibility to primoinfection, which is connected with increased complication risk. Primoinfection can be diagnosed using anti-BKV IgG seroconversion.