The detection of herpes infections is based on the determination of antibody titers by ELISA. Monitoring of the dynamics of specific antibodies in the IgG and IM classes allows indirect diagnosis of diseases caused by or associated with this herpes virus.
For testing of the detection of anti-HHV-6 antibodies IgG and IgM isotypes in serum/plasma/cerebrospinal fluid, we provide our traditional immunoenzymatic kits ELISA-VIDITEST and MONO-VIDITEST and the IF-VIDITEST immunofluorescence kit. VIDITEST kits comes from our own research and production.
ELISA-VIDITEST uses 96-well microtiter plates, while MONO-VIDITEST cassette 12-well format. All testing and evaluation takes place automatically in combination with our VIDIMAT analyzer.
The ELISA-VIDITEST anti-HHV-6 IgG (CSF) kits can be used to calculate intrathecal synthesis of anti-HHV-6 IgG antibodies in cerebrospinal fluid.
Elevated IgG antibodies may be the only indicator of reactivated chronic central nervous system (CNS) HHV-6 infection.
The determination of the presence of IgG anti-HHV-6 antibodies allows assessment of the patient's immune status. The seroconversion or 4-fold increase of the antibody titer in paired samples indicate active infection.
About virus
Human herpesvirus 6 (HHV-6) is a double-stranded DNA virus in the subfamily Betaherpesviriniaea of the genus Roseolovirus. It was first discovered in 1986. The virus occurs in two unique variants, HHV-6A and HHV-6B. Within them, 95 % is sequence homology. Nevertheless, they differ in restriction endonuclease cleavage, monoclonal antibody response, virulence, and clinical manifestations of their infection.