In reversed-phase chromatography, polar compounds are eluted first, causing routine and complex separation challenges. With convergence chromatography, however, polar compounds are retained and eluted last - providing the separation power of normal-phase liquid chromatography (LC) with the ease-of-use of reversed-phase LC.
Using green and non-toxic compressed liquid CO2 as a primary mobile phase, the ACQUITY UPC2® System delivers the ability to precisely vary mobile phase strength, pressure, and temperature. The ability to fine-tune the resolving power and selectivity of the system, enables better control over the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diastereomeric mixtures - all compounds that are often a challenge to separate by any other means.
Overview
The chromatographic principles and selectivity of normal-phase LC
The ease of use and method development simplicity of reversed-phase LC
The use of gradients across the widest polarity range
Chiral and achiral separations in one system, with unequaled speed and confidence
Recommended Use: To solve routine and complex separations challenges that require unparalleled selectivity and ease-of-use.
Bringing ease of use to normal-phase LC
By providing the ability to precisely vary mobile phase strength, pressure, and temperature, the Waters ACQUITY UPC2 System gives scientists the power to better control the retention of analytes for separating, detecting, and quantifying structural analogs, isomers, and enantiomeric and diastereomeric mixtures.