In almost any laboratory or research and scientific facility, there are numerous devices, instruments, or processes that require gases to run the instrumentation or process or to calibrate the devices. Gas cylinders that are located in the laboratory area can present significant hazards, and the space they take up can be better used for other more appropriate purposes. Gas delivery systems that are properly designed, sized, and located can improve safety in the laboratory. In addition, attention to high-purity requirements—purity, compatibility, flow, materials of construction, and more—is vital for safety, performance, and cost-efficiency.