Lung cancer detection kit YZYMT-001

colorectal cancerfor genotypingfor the KRAS gene

Human KRAS Gene Mutations Detection Kit (PCR-Fluorescence Probe Method) This product is used for qualitative detection of 7 somatic mutations in codons 12,13 of KRAS gene in human genomic DNA extracted from formalin-fixed paraffin-embedded (FFPE） tumor tissue KRAS is a proto-oncogene, about 35 kb in length, located on chromosome 12. It is a member of the RAS gene family. The protein encoded by the gene is related to tumor formation, proliferation, migration, diffusion and angiogenesis. The mutation probability of KRAS gene is very high in various tumors. The common mutation sites are codon 12 and codon 13 of exon 2 of KRAS gene. The most common seven mutation hot spots are : G12C, G12S, G12R, G12V, G12D, G12A, G13D, which account for more than 98.5 % of all mutations.