Colorectal cancer detection kit YZYMT-019

for genotypinggeneticFFPE tissues

Human NRAS Gene Mutations Detection Kit (PCR-Fluorescence Probe Method) This product is used for qualitative detection of 9 types of NRAS gene in exons 2, 3 and 4 of NRAS gene in DNA specimen of paraffin-embedded section of patients. NRAS gene, located on chromosome 1p31, is a member of RAS family with GTP enzyme activity and a key regulator in cell growth, proliferation and differentiation. NRAS gene has been found to have activated mutations in a variety of cancers, including melanoma (15-25%) [1] and colorectal cancer (2-6%) [2]. The common mutation sites of NRAS are located in exons 2, 3 and 4 of the gene, mainly concentrated in codons 12, 13, 59, 61, 117 and 146 [3] [4]. Studies have found that in colorectal cancer patients, when KRAS gene exon 2 is wild-type, the mutation frequency of NRAS gene exon 2 (codon 12, 13) is 3.8%, and that of Nras gene exon 3 (codon 59, 61) is 4.8%. The mutation frequency of exon 4 (codon 117, 146) is 0.5%[4] .