Introduction
PRL is a single chain protein, secreted by antepituitary basophil, which consist of 199 amino acids with molecular weight of 23kDa. PRL has the function of promoting proliferation of mammary gland and lactation. The level of PRL rises up during pregnancy, reaches its peak when delivery, then declines after lactication. Lactication with newborn will bring about an increase of the concentration. The concentration of PRL in blood rises up when there is pituitary tumor occurring, such as prolactin-producing tumor, acromegalia, primary hypothyroidism, cancer, hypothalamus tumor[1-3].
Advantages
✔ Low sample requirements: direct testing of trace serum without dilution
✔ As one of the evaluation indicators of adenohypophyseal function, it is often combined with FSH/LH to detect sexual function
Clinical Significance
✔ Contribute to the diagnosis of hypothalamic pituitary dysfunction
✔ Auxiliary diagnosis of primary hypothyroidism
✔ The development of sexual signs can be assessed
Application
Laboratory, Outpatient, Gynecology, Endocrinology, Reproductive Center
Reference
1.Wei Yang. The role of pituitary prolactin receptor (PRLr) in the immune system [J]. Japan Medical Introduction, 2000, 21 (10): 472-473.
2.Wu Qinyong. Establishment and primary clinical application of human serum prolactin immuno-radiometric assay [J]. 1997, 17 (2): 119-120.
3.Tu Yong. Determination of progesterone, testosterone and pituitary prolactin by magnetic separation enzyme-linked immunosorbent assay [J] Bed Magazine, 1999, 6 (2): 132-133.