Cardiovascular disease test kit BIOT-YG-I, FLI-600

NT-proBNPserumplasma

Introduction: NT-proBNP is a polypeptide mainly comes from ventricle. Cardiomyocytes synthesize a pre-propeptide preproBNP with 134 amino acids, which is split into a signal peptide and a propeptide (proBNP with 108 amino acids). During secretion from the cardiomyocytes, proBNP is split in a ratio of 1:1 into a physiologically active C-terminal fragment BNP (with 32 amino acids) and a biologically inactive N-terminal fragment NT-proBNP (with 76 amino acids). In physiologically, 70% of NT-proBNP is secreted by ventricle because of the large mass of ventricle. Aside from ventricle, NT-proBNP is also secreted by other organs such as brain, kidney, aorta and adrenal gland. However the level is far less than cardiac.It was advocated as a beneficial biomarker for evaluating HF by the American Association for Clinical Chemistry in 2007 and is allowed to be used for diagnosis and evaluation of HF and ACS by FDA. [1-3]. Advantage: 1. The half-life is 90-120 minutes. In vitro stability, positive predictive value, and anti-drug interference effects are better than BNP. NT-proBNP is more sensitive than BNP in detecting early or mild heart failure. 2. Low sample requirements: whole blood can be processed without centrifugation 3. Equipped with special dropper consumables, more suitable for clinical operation scenarios Clinical significance: 1. Used to distinguish cardiogenic and pulmonary dyspnea 2. Used to assess the degree of heart failure and predict the survival rate of patients with acute decompensated heart failure Intended use: ICU, Respiratory Medicine, Emergency department