Leica immunohistochemistry reagents

... and possibly PBS-based antibody diluents gives increased background staining and decreased staining intensity. Proprietary reagents from Leica Biosystems or TBS-based wash buffer and diluents are recommended. Disclaimer Akt ...

Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated ...

Antigen Background Alpha Fetoprotein (AFP) is an oncofetal antigen of 70 kD found in body fluids, which if detected in high concentrations has clinical implications. AFP is expressed in fetal liver but is not present under normal circumstances ...

Antigen Background Alpha-methylacyl-CoA racemase (AMACR), also known as p504s, is a mitochondrial and peroxisomal enzyme that is involved in bile acid biosynthesis and beta-oxidation of branched-chain fatty acids. AMACR is essential ...

Antigen Background Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a ...

... the action of male sex hormones (androgens). The androgen receptor has wide distribution and can be demonstrated by immunohistochemistry in several tissues e.g. prostate, skin, and oral mucosa. Androgen receptor has been ...

Analyte Specifc Reagent Statement Analyte Specific Reagent. Analytical and performance characteristics are not established.

Antigen Background Bcl-2 is a member of a family of proteins that are involved in apoptosis. Bcl-2 is an integral inner mitochondrial membrane protein of 25 kD and has a wide tissue distribution. It is considered to act as an inhibitor ...

... non-Hodgkin's lymphomas and Bcl-6 rearrangements have also been detected in 33-45% of diffuse large B cell lymphomas. Immunohistochemistry has been reported to show the Bcl-6 gene product to be detectable in follicular ...

... anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway ...